This Policy Forum sets forth some of the most disruptive changes witnessed over the past decade, and assesses their impact on the security environment. It goes on to emphasize the need for security governance approaches and frameworks that are flexible and adaptive to changing security landscapes. In doing so, the Policy Forum exemplifies the European Union’s (EU) pursuit of such a framework to effectively address these changes, in the form of the EU Centres of Excellence Initiative on Chemical, Biological, Radiological, and Nuclear (CBRN) Risk Mitigation.