In an environment of global geopolitical transition, long-standing alliance patterns erode. At the same time, the multiple uncertainties over how the world of tomorrow will be governed, by whom, and under which norms, appear to favor interest-based cooperation among geopolitical actors alongside more structural partnerships. In the Middle East and North Africa, the past decade has seen both erosion and consolidation of long-standing partnerships, and the emergence of a variety of interest-based cooperation, adding up to a complex web of overlapping, alliances, interests and antagonisms. The present workshop seeks to take a closer look at old and new patterns of Middle Eastern alliances. It will attempt to assess the major changes in regional cooperation trends both among states and between states and non-state actors. It will then seek to identify clusters of new alliance paradigms, and discuss the impact the combination of these new patterns may have on the future of the region’s geopolitics and security.