The SARS-CoV-2 virus is dangerous not so much because of the direct damage done to living cells, but because of the accompanying complications that it triggers. The overall health status of the affected body is what matters, alongside chronic diseases and susceptibilities. The impact of the pandemic on global politics is somewhat similar: the lockdown and economic disruption exacerbate the accumulated contradictions and problems. From this perspective, the pandemic hit the U.S. at a bad time in terms of both its domestic political landscape and the foreign policy it has adopted in recent years. The active yet chaotic and hazardous game with opponents and partners that Donald Trump picked as his strategy can bear fruit only in certain conditions. Achieving success requires a robust economy (in 2017–2019, the U.S. economy grew at a rate of 2%–3%), as well as readily available reserves, fast response capability, confidence and an image of success.